External Links: The Centre for Macular Research at UBC
Dr. R.S. Molday, Professor & Division Head
Dr. D. Albiani, Clinical Assistant Professor
Dr. J. Barton, Professor
Dr. R.M. Douglas, Associate Professor
Dr. C. Y. Gregory-Evans, Associate Professor
Dr. K. Gregory-Evans, Professor
Dr. A. Kirker, Clinical Assistant Professor
Dr. P. Ma, Clinical Professor
Dr. D. Maberley, Professor
Dr. J.A. Matsubara, Professor
Dr. A. Merkur, Clinical Assistant Professor
Dr. O.L. Moritz, Associate Professor
Dr. M. Potter, Visiting Professor
Dr. W. Ross, Clinical Professor
Dr. N. Swindale, Professor
The Centre for Macular Research (CMR) is leading the way with a research
program focused on macular degeneration and other diseases affecting vision.
The centre’s strength lies in the expertise and accomplishments
of its faculty, coupled with the university’s partnerships with
the teaching hospitals. Healthcare, both locally in BC and nationally
in Canada, is advanced by the Centre’s commitment to excel in basic
science, translational research and clinical expertise, and towards finding
a cure for blindness.
The CMR is affiliated with both the University of British Columbia (UBC) and Vancouver Coastal Health Research Institute (VCHRI).
The mission of the VCHRI is to ensure that research in the health authority “leads and excels in the generation of health knowledge through discovery, education, application and evaluation”. In line with this mission, the goal of the CMR is to combine its strength in basic and translational science with the centre’s clinical expertise to lead the way towards new treatments and cures for retinal disease.
The CMR represents collaboration between faculty members of the Department of Ophthalmology and Visual Sciences, the Department of Biochemistry and Molecular Biology and the Brain Research Centre at the University of British Columbia. This impressive team of basic and clinical scientists have come together to create an interdisciplinary environment to maximize scientific discovery and train the next generation of researchers and clinicians.
Coleman JA and Molday RS. Critical role of the beta-subunit CDC50A in the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2 . J Biol Chem . 286:17205-16. (2011).
Azadi S, Molday LL, and Molday RS. RD3, the protein associated with Leber congenitalamaurosis type 12, is required for guanylatecyclase trafficking in photoreceptor cells. ProcNatlAcadSci U S A . 107:21158-63. (2010).
Molday RS and Zhang K . Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degeneration . Prog Lipid Res . 49:476-92. (2010).
Tam BM and Moritz OL. The role of rhodopsin glycosylation in protein folding, trafficking, and light-sensitive retinal degeneration . J Neurosci .29:15145-54 (2009).
Tam BM, Qazalbash A, Lee HC, and Moritz OL. The dependence of retinal degeneration caused by the rhodopsin P23H mutation on light exposure and vitamin a deprivation . Invest Ophthalmol Vis Sci . 51:1327-34 (2010).
Lee DC, Xu J, Sarunic MV, and Moritz OL . Fourier domain optical coherence tomography as a noninvasive means for in vivo detection of retinal degeneration in Xenopuslaevis tadpoles. Invest Ophthalmol Vis Sci. 51:1066-70 (2010).
Gregory-Evans K, Po K, Chang F, and Gregory-Evans CY . Pharmacological Enhancement of ex vivo Gene Therapy Neuroprotection in a Rodent Model of Retinal Degeneration . Ophthalmic Res . 47:32-38. (2011).
Gregory-Evans CY, Moosajee M, Shan X, and Gregory-Evans K . Gene-specific differential response to anti-apoptotic therapies in zebrafish models of ocular coloboma . Mol Vis . 17:1473-84 (2011).
Moosajee M, Gregory-Evans K, Ellis CD, Seabra MC, and Gregory-Evans CY. Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease . Hum Mol Genet . 17:3987-4000. (2008).
Oruç I, Guo XM, and Barton JJ. Gender in facial representations: a contrast-based study of adaptation within and between the sexes . PLoS One . 18;16251. (2011).
Barton JJ. Disorder of higher visual function . CurrOpin Neurol . 24:1-5. (2011).
Pfeffer G, Abegg M, Vertinsky AT, Ceccherini I, Caroli F, and Barton JJ. The ocular motor features of adult-onset alexander disease: a case and review of the literature . J Neuroophthalmol . 31:155-9. (2011).
Kurji KH, Cui JZ, Lin T, Harriman D, Prasad SS, Kojic L, and Matsubara JA. Microarray analysis identifies changes in inflammatory gene expression in response to amyloid-beta stimulation of cultured human retinal pigment epithelial cells . Invest Ophthalmol Vis Sci . 51:1151-63. (2010).
Tsai GY, Cui JZ, Syed H, Xia Z, Ozerdem U, McNeill JH, and Matsubara JA. Effect of N-acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats. Clin Experiment Ophthalmol .37:223-31 (2009).
Cui JZ, Wang XF, Hsu L, and Matsubara JA . Inflammation induced by photocoagulation laser is minimized by copper chelators . Lasers Med Sci. 24:653-7. (2009)